Abstract

Refractory hypotension is an increasing perioperative concern most prominently seen in patients on chronic renin-angiotensin-aldosterone system (RAAS) inhibitors. Angiotensin-converting enzyme inhibitors (ACE inhibitors), angiotensin II receptor blockers (ARBs), or a combination of the two therapies are common first-line medications used to treat primary hypertension. Despite the benefit of managing hypertension, such therapies do not come without complications. The principal mechanism of RAAS inhibitors is by inducing vasodilation by decreasing angiotensin II. However, this poses limitations during surgical events managed under general anesthesia...

Author Details

Cristina Basulescu Pfister MSN, SRNA; Amy Snow, DNP, CRNA

Sigma Membership

Non-member

Type

DNP Capstone Project

Format Type

Text-based Document

Study Design/Type

Case Study/Series

Research Approach

Translational Research/Evidence-based Practice

Keywords:

Angiotensin-Converting Enzyme Inhibitor (ACE-inhibitor), General Anesthesia, Refractory Hypotension, Perioperative Hypotension, Vasopressin

Advisor

Amy Snow

Degree

DNP

Degree Year

2025

Rights Holder

All rights reserved by the author(s) and/or publisher(s) listed in this item record unless relinquished in whole or part by a rights notation or a Creative Commons License present in this item record. All permission requests should be directed accordingly and not to the Sigma Repository. All submitting authors or publishers have affirmed that when using material in their work where they do not own copyright, they have obtained permission of the copyright holder prior to submission and the rights holder has been acknowledged as necessary.

Review Type

None: Degree-based Submission

Acquisition

Proxy-submission

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Abstract.pdf (178 kB)

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