Abstract
It is estimated that 9-37% of all mechanically ventilated patients experience difficulty during weaning from mechanical ventilation (MV). Weaning may be problematic for individuals with co-existing cardiac dysfunction, since hemodynamic instability is one proposed cause of weaning failure. Hemodynamic instability during weaning may develop with transition from positive intrathoracic pressure (ITP) during inspiration with MV to the negative ITP with spontaneous ventilation. This ITP shift may induce changes in right ventricular preload, afterload and contractility. The purpose of this study was to describe changes in right heart hemodynamics associated with weaning. Twenty instrumented, anesthetized, canines were randomly assigned to Group 1, normal ventricular function (n = 10), or Group 2, propranolol induced biventricular failure (n = 10). Each subject was randomly exposed to 4 weaning permutations: spontaneous ventilation (T-piece), spontaneous ventilation with a resistor (Resistor), pressure support 5 cm.
Sigma Membership
Delta Psi at-Large, Epsilon
Type
Dissertation
Format Type
Text-based Document
Study Design/Type
Other
Research Approach
Quantitative Research
Keywords:
Patient Care, Mechanical Ventilation Removal, Cardiac Care
Advisor
Kathleen S. Stone
Degree
PhD
Degree Grantor
The Ohio State University
Degree Year
1996
Recommended Citation
Frazier, Susan Kay, "Right heart hemodynamics during weaning from mechanical ventilation" (2019). Dissertations. 642.
https://www.sigmarepository.org/dissertations/642
Rights Holder
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All permission requests should be directed accordingly and not to the Sigma Repository.
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Review Type
None: Degree-based Submission
Acquisition
Proxy-submission
Date of Issue
2019-11-20
Full Text of Presentation
wf_yes
Description
This dissertation has also been disseminated through the ProQuest Dissertations and Theses database. Dissertation/thesis number: 9630891; ProQuest document ID: 304285184. The author still retains copyright.